Invention Grant
- Patent Title: Formulation for anti-α4β7 antibody
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Application No.: US14114832Application Date: 2012-05-02
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Publication No.: US09764033B2Publication Date: 2017-09-19
- Inventor: Willow Diluzio , Nobel T. Truong , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown , Catherine Scholz
- Applicant: Willow Diluzio , Nobel T. Truong , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown , Catherine Scholz
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agent Cristin H. Cowles
- International Application: PCT/US2012/036072 WO 20120502
- International Announcement: WO2012/151248 WO 20121108
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/26 ; A61K47/18 ; C07K16/28 ; A61K9/00 ; A61K9/19 ; A61K39/00
Abstract:
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
Public/Granted literature
- US20140377251A1 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY Public/Granted day:2014-12-25
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