A vehicle frame structure including: an elongated inner panel that is disposed at a vehicle cabin inner side of a vehicle body side section; an elongated outer panel that is disposed at the vehicle cabin outer side of the inner panel, and that, together with the inner panel, configures a frame by being joined to the inner panel; an elongated reinforcement member that is disposed at the vehicle cabin outer side or the vehicle cabin inner side of the outer panel, and that reinforces the outer panel by being joined to plural locations of the outer panel along the length direction; and a first excess length portion that is formed at the reinforcement member between adjacent joining portions between the reinforcement member and the outer panel, and that has excess length in a direction linking the joining portions.