Invention Grant
- Patent Title: PRMT5 inhibitors and uses thereof
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Application No.: US14995092Application Date: 2016-01-13
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Publication No.: US09765068B2Publication Date: 2017-09-19
- Inventor: Kenneth W. Duncan , Richard Chesworth , Paula Ann Boriack-Sjodin , Michael John Munchhof , Lei Jin
- Applicant: Epizyme, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Epizyme, Inc.
- Current Assignee: Epizyme, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D413/02
- IPC: C07D413/02 ; C07D413/12 ; C07D401/14 ; C07D405/14 ; C07D217/16 ; C07D401/12 ; C07D405/12 ; C07D417/12 ; C07D217/04 ; A61K31/472 ; A61K31/4725 ; A61K31/497 ; A61K31/498 ; A61K31/502 ; A61K31/517 ; A61K31/5377 ; A61K31/538 ; C07D217/08
Abstract:
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
Public/Granted literature
- US20160368907A1 PRMT5 INHIBITORS AND USES THEREOF Public/Granted day:2016-12-22
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