Invention Grant
- Patent Title: Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
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Application No.: US14899008Application Date: 2014-06-16
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Publication No.: US09765107B2Publication Date: 2017-09-19
- Inventor: Stephane Bogen , Vinay Girijavallabhan , Quang Truong , Ping Chen , Frank Bennett , Angela Kerekes , Qun Dang , David B. Olsen , Ian Davies
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Jeffrey P. Bergman; Catherine D. Fitch
- International Application: PCT/US2014/042463 WO 20140616
- International Announcement: WO2014/204831 WO 20141224
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H19/10 ; A61K45/06 ; A61K31/661 ; C07F9/6558 ; C07F9/6574 ; C07H19/11 ; A61K31/7072 ; A61K31/7068 ; A61K31/706 ; A61K31/7064
Abstract:
The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein, as well as to compositions and methods of using the Cyclic Phosphonate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
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