Invention Grant
- Patent Title: Method for producing a phytase variant with improved thermal stability, and a phytase variant and the use thereof
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Application No.: US15112198Application Date: 2013-11-12
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Publication No.: US09765313B2Publication Date: 2017-09-19
- Inventor: Bin Yao , Huoqing Huang , Huiying Luo , Chao Shao , Yingguo Bai , Yaru Wang , Peilong Yang , Pengjun Shi , Kun Meng , Heng Zhao , Rui Ma
- Applicant: FEED RESEARCH INSTITUTE
- Applicant Address: CN Beijing
- Assignee: Feed Research Institute, Chinese Academy of Agricultural Sciences
- Current Assignee: Feed Research Institute, Chinese Academy of Agricultural Sciences
- Current Assignee Address: CN Beijing
- Agency: PatShegen IP
- International Application: PCT/CN2013/086943 WO 20131112
- International Announcement: WO2015/070372 WO 20150521
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C12N15/63 ; C12N1/20 ; C12N1/14 ; C12N15/52 ; A23K20/189
Abstract:
The present invention relates to the field of genetic engineering, in particular, the present invention relates to a method for producing a phytase variant with an improved thermal stability, and a phytase variant and the use thereof. The phytase variant contains at least one proline modification, compared to the phytase from Escherichia coli and other mutants thereof. The phytase variants with the modification have preferably improved properties, such as the thermal stability, optimal reaction temperature, pH property, specific activity, protease resistance and performance in animal feeds.
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