Invention Grant
- Patent Title: Chimeric antigen receptors targeting B-cell maturation antigen
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Application No.: US14389677Application Date: 2013-03-15
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Publication No.: US09765342B2Publication Date: 2017-09-19
- Inventor: James Noble Kochenderfer
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer
- International Application: PCT/US2013/032029 WO 20130315
- International Announcement: WO2013/154760 WO 20131017
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K16/26 ; C12N15/62 ; C07K14/725 ; C07K16/28 ; C07K16/18 ; A61K48/00 ; A61K39/00
Abstract:
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
Public/Granted literature
- US20150051266A1 CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN Public/Granted day:2015-02-19
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