Invention Grant
- Patent Title: Biosensors engineered from conditionally stable ligand-binding domains
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Application No.: US14993509Application Date: 2016-01-12
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Publication No.: US09766255B2Publication Date: 2017-09-19
- Inventor: George M. Church , Justin Feng , Daniel J. Mandell , David Baker , Stanley Fields , Benjamin Ward Jester , Christine Elaine Tinberg
- Applicant: President and Fellows of Harvard College , University of Washington
- Applicant Address: US MA Cambridge US WA Seattle
- Assignee: President and Fellows of Harvard College,University of Washington
- Current Assignee: President and Fellows of Harvard College,University of Washington
- Current Assignee Address: US MA Cambridge US WA Seattle
- Agency: Banner & Witcoff, Ltd.
- Main IPC: C12N7/00
- IPC: C12N7/00 ; G01N33/74
Abstract:
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.
Public/Granted literature
- US20160202256A1 Biosensors Engineered from Conditionally Stable Ligand-Binding Domains Public/Granted day:2016-07-14
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