A mutual capacitance touch sensing device and a sine wave measuring method is disclosed. A sine wave generator of a driver and sensor module of a touch sensing panel of the mutual capacitance touch sensing device uses a clock to generate multiple sine waves according to a lookup table being loaded therein, enabling a selective circuit to transmit the sine waves to driving lines of the touch sensing panel in a proper order so that each sine wave at each driving line is capacitive-coupled to a respective sensing line through a respective crossover point to produce a respective sensing signal, and then a measurement unit scans the generated sensing signal subject to the lookup table in the sine wave generator and then provides the measured signals to a processor for processing.