A multi-channel sound (MCS) system features intelligent calibration (e.g., of acoustic echo cancellation (AEC)) for use in dynamic acoustic environments. A sensor subsystem is utilized to detect and identify changes in the acoustic environment and determine a “scene” corresponding to the resulting acoustic characteristics for that environment. This detected scene is compared to predetermined scenes corresponding to the acoustic environment. Each predetermined scene has a corresponding pre-tuned filter configuration for optimal AEC performance. Based on the results of the comparison, the pre-tuned filter configuration corresponding to the predetermined scene that most closely matches the detected scene is utilized by the AEC subsystem of the multi-channel sound system.