A smart luggage system includes a smart luggage assembly having a case assembly with a first stowage compartment and a second stowage compartment. First and second lock assemblies retain first and second stowage compartments in a closed and locked orientation, respectively. A transport assembly is mounted to the case assembly to facilitate movement thereof. A smart handle assembly is also mounted to a case assembly. The smart handle assembly includes a controller having a wireless communication interface, and further includes a power supply. A smart luggage system also includes a smart luggage mobile interface which is operative on a mobile device, and is communicative with a controller of a smart handle assembly via a wireless communication interface.