A vessel for e.g. well intervention or deep sea lowering, comprises a moon pool and a hoisting arrangement for lowering and retrieving items, in particular equipment, tools, and/or supplies or modules comprising the same, through the moon pool, into respectively from the sea and onto respectively from the seabed or an installation on the seabed. The vessel further comprises one or more guides for laterally retaining items inside the moon pool, preferably at least two guides positioned on opposite sides of the moon pool.