Invention Grant
- Patent Title: Wnt signaling inhibitor
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Application No.: US14908945Application Date: 2014-07-29
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Publication No.: US09771351B2Publication Date: 2017-09-26
- Inventor: Hiroshi Ishida , Keiichi Motosawa , Yusuke Miura , Ryuichiro Nakai , Ryoko Okada , Yuichi Takahashi
- Applicant: KYOWA HAKKO KIRIN CO., LTD.
- Applicant Address: JP Chiyoda-ku
- Assignee: KYOWA HAKKO KIRIN CO., LTD.
- Current Assignee: KYOWA HAKKO KIRIN CO., LTD.
- Current Assignee Address: JP Chiyoda-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2013-156458 20130729
- International Application: PCT/JP2014/069872 WO 20140729
- International Announcement: WO2015/016195 WO 20150205
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D475/00 ; C07D405/14 ; C07D413/14 ; C07D471/04 ; C07D487/04 ; C07D491/052 ; C07D491/056 ; C07D498/04 ; C07D519/00

Abstract:
A Wnt signaling inhibitor which comprises, as an active ingredient, a fused-ring heterocyclic compound represented by the following formula (IA) or a pharmaceutically acceptable salt thereof, and the like are provided: (wherein, n1A represents 0 or 1; n2A and n3A may be the same or different, and each represents 1 or 2; ROA represents optionally substituted aryl or the like; R2A represents a hydrogen atom or the like; R3A represents an optionally substituted aromatic heterocyclic group or the like; X1A, X2A, X3A and X4A each represent CH or the like; Y1A represents CH2 or the like; Y2A represents N or the like; and LA represents CH2 or the like).
Public/Granted literature
- US20160168125A1 WNT SIGNALING INHIBITOR Public/Granted day:2016-06-16
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