Invention Grant
- Patent Title: Indazole compounds useful as ketohexokinase inhibitors
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Application No.: US14338816Application Date: 2014-07-23
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Publication No.: US09771375B2Publication Date: 2017-09-26
- Inventor: Xuqing Zhang , Marta C Abad , Alan C. Gibbs , Gee-Hong Kuo , Fengbin Song , Zhihua Sui , Lawrence C. Kuo
- Applicant: JANSSEN PHARMACEUTICA NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: Baker & Hostetler LLP
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P3/10 ; A61P3/04 ; A61P3/06 ; C07D471/04 ; C07D491/08 ; C07D231/56 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/10 ; C07D403/12 ; C07D487/10 ; A61K31/437

Abstract:
The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
Public/Granted literature
- US20140336170A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS Public/Granted day:2014-11-13
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