Invention Grant
- Patent Title: Process for preparing tubulysins
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Application No.: US14771532Application Date: 2014-02-28
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Publication No.: US09771391B2Publication Date: 2017-09-26
- Inventor: Iontcho Radoslavov Vlahov , Christopher Paul Leamon
- Applicant: ENDOCYTE, INC.
- Applicant Address: US IN West Lafayette
- Assignee: Endocyte, Inc.
- Current Assignee: Endocyte, Inc.
- Current Assignee Address: US IN West Lafayette
- Agency: Barnes & Thornburg LLP
- International Application: PCT/US2014/019605 WO 20140228
- International Announcement: WO2014/134543 WO 20140904
- Main IPC: C07K5/00
- IPC: C07K5/00 ; C07K5/02 ; C07K5/062 ; C07D417/14 ; C07D417/12 ; C07K5/097
Abstract:
The invention described herein pertains to processes for preparing tubulysins and derivatives thereof. The invention described herein also pertains to processes for preparing tubulysin conjugates. The invention described herein also pertains to processes for preparing intermediates for preparing tubulysin conjugates. In one step, the alpha-thiazolyl alcohol is protected with triethylsilyl chloride in the presence of imidazole in an aprotic solvent.
Public/Granted literature
- US20160016993A1 PROCESS FOR PREPARING TUBULYSINS Public/Granted day:2016-01-21
Information query
