Invention Grant
- Patent Title: Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors
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Application No.: US14197173Application Date: 2014-03-04
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Publication No.: US09771430B2Publication Date: 2017-09-26
- Inventor: Ira Tabas , Lale Ozcan
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: A61K31/00
- IPC: A61K31/00 ; C12N9/99 ; C07K16/40 ; A01K67/027 ; C07K14/705 ; C12N9/12 ; A61K31/47 ; A61K31/472 ; C12N15/113 ; G01N33/50
Abstract:
The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors or activators of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1, Dach2, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach, or activates CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2.
Public/Granted literature
- US20140314789A1 CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY Public/Granted day:2014-10-23
Information query
