Invention Grant
- Patent Title: High-throughput image-based chemical screening in zebrafish blastomere cell culture
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Application No.: US14384514Application Date: 2013-03-14
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Publication No.: US09771560B2Publication Date: 2017-09-26
- Inventor: Leonard I. Zon , Cong Xu , Amy J. Wagers , C. Ronald Kahn
- Applicant: CHILDREN'S MEDICAL CENTER CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , JOSLIN DIABETES CENTER INC.
- Applicant Address: US MA Boston US MA Cambridge US MA Boston
- Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,JOSLIN DIABETES CENTER INC.
- Current Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,JOSLIN DIABETES CENTER INC.
- Current Assignee Address: US MA Boston US MA Cambridge US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick
- International Application: PCT/US2013/031504 WO 20130314
- International Announcement: WO2013/138623 WO 20130919
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/077 ; G01N33/50 ; G01N33/569 ; A61K38/18 ; A61K38/28 ; A61K38/30 ; A61K35/545
Abstract:
Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof. Also disclosed is a screening assay for screening test compounds using blastomere cultures.
Public/Granted literature
- US20150147807A1 HIGH-THROUGHPUT IMAGE-BASED CHEMICAL SCREENING IN ZEBRAFISH BLASTOMERE CELL CULTURE Public/Granted day:2015-05-28
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