Invention Grant
- Patent Title: Pharmaceutical composition consisting of RNA having alkali metal as counter ion and formulated with dications
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Application No.: US13919663Application Date: 2013-06-17
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Publication No.: US09771594B2Publication Date: 2017-09-26
- Inventor: Steve Pascolo
- Applicant: Steve Pascolo
- Applicant Address: CH
- Assignee: spRNA GmbH
- Current Assignee: spRNA GmbH
- Current Assignee Address: CH
- Agency: St Onge Steward Johnston and Reens LLC
- Priority: EP10195493 20101216
- Main IPC: C12N15/117
- IPC: C12N15/117 ; A61K9/00 ; A61K47/02 ; C12N15/88 ; C12N15/11 ; C12N15/113
Abstract:
A biologically active RNA-alkali metal-dication formulation, a pharmaceutical composition containing the complexes, and methods of producing the same. The formulation is particularly useful to introduce RNA and an attached cargo into cells allowing its biological intracellular activities: e.g. immunostimulation (immunomodulation), RNA interference or gene expression.
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