Invention Grant
- Patent Title: 4-miRNA signature for predicting clear cell renal cell carcinoma metastasis and prognosis
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Application No.: US13284735Application Date: 2011-10-28
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Publication No.: US09771619B2Publication Date: 2017-09-26
- Inventor: Huiqing Wu , Xiwei Wu
- Applicant: Huiqing Wu , Xiwei Wu
- Applicant Address: US CA Duarte
- Assignee: CITY OF HOPE
- Current Assignee: CITY OF HOPE
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Agent Lara J. Dueppen
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12Q1/68
Abstract:
An miRNA expression signature comprising a set of one or more miRNAs associated with metastatic cancer is provided. In one embodiment, the expression signature is selected from the group consisting of miR-10b, miR-139-5p, miR-130b and miR-199b-5p. In some aspects, miR-199b-5p and miR-130b are overexpressed in metastatic cancer; and miR-10b and miR-139-5p are downregulated in metastatic cancer. Such an expression signature may be used in methods for predicting metastasis, risk for developing metastasis or a prognosis in a cancer. In another embodiment, a method for establishing such a cancer miRNA expression signature is provided.
Public/Granted literature
- US20120108446A1 4-miRNA SIGNATURE FOR PREDICTING CLEAR CELL RENAL CELL CARCINOMA METASTASIS AND PROGNOSIS Public/Granted day:2012-05-03
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