The present invention relates to a high-strength high-toughness steel plate and a method of manufacturing the steel plate. The steel plate contains the following chemical compositions, by weight, C: 0.03-0.06%, Si≦0.30%, Mn: 1.0-1.5%, P≦0.020%, S≦0.010%, Al: 0.02-0.05%, Ti: 0.005-0.025%, N≦0.006%, Ca≦0.005%, and more than one of Cr≦0.75%, Ni≦0.40%, Mo≦0.30%, other compositions being Ferrum and unavoidable impurities. The finished steel plate, with a thickness of 6-25 mm, has a yield strength of ≧700 MPa, an elongation A50 of ≧18%, Akv at −60° C. of ≧150 J and good cool bending property.