A modular frame and structure system and method includes a framework and a cover coupled to the framework and configured to provide a desired structure. The framework includes a plurality of elongated frame members, and a plurality of coupling members for coupling the elongated frame members. One or more of the coupling members includes a releasable connecting device having a connecting mode for connecting the coupling members to the frame members and form the framework, the releasable connecting device having a release mode for disconnecting the elongated frame members from the coupling members. The cover includes one or more interlocking wall panels configured to engage and be supported by the elongated frame members, and one or more interlocking roof panels configured to engage and be supported by the elongated frame members.