A KeyMod handguard quick release structure is mainly used in rifle gun, including a base body for mounting gun accessories, operation elements, first spring element fixed to each operation element, a positioning element and a second spring element installed between the positioning element and base body, where the seat body has an accommodation space and through hole, the operation elements respectively have a guide portion, and the positioning element is passed through the through-hole. When the base body is to be installed on the KeyMod handguard, an engagement member is placed in a large engagement hole, and the base body is then pressed down, the positioning element being moved upward immediately.