An image sensor capable of preventing generation of a line-type defect is disclosed. The image sensor includes a row driver, a pixel array, an analog signal processor, a data mapping buffer and a row data buffer. The pixel array has a layout configuration having a nonlinear pattern for a row path and a column path, receives optical signals and converts the optical signals into electric signals, and outputs the electric signals as image signals in response to the pixel control signals. The analog signal processor performs analog-to-digital conversion on the image signals to generate first signals. The data mapping buffer compensates position errors caused by the layout configuration of the zigzag pattern for the first signals to generate a second signals.