Invention Grant
- Patent Title: Vaccine composition comprising an immunogenic protein and combination adjuvants for use in eliciting antigen-specific T-cell responses
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Application No.: US15052713Application Date: 2016-02-24
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Publication No.: US09775898B2Publication Date: 2017-10-03
- Inventor: Chia-Mao Wu , Jiun-Ming Wu , Yi-Tsui Chiu , Yin-Ching Lin , Hsien-Kai Chuang , Fu-Tan Hsieh , Kuan-Ming Chen
- Applicant: TheVax Genetics Vaccine Co., Ltd.
- Applicant Address: TW Taipei
- Assignee: TheVax Genetics Vaccine Co., Ltd.
- Current Assignee: TheVax Genetics Vaccine Co., Ltd.
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61K38/16 ; A61K38/17 ; A61K39/12 ; C12N7/00 ; A61K39/00
Abstract:
Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826.
Public/Granted literature
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