A storage bag includes first and second sidewalls each having a top edge, a top portion, and a bottom portion. The bottom portion of the first sidewall includes at least one shift region about which the bag is capable of shifting. The shift region includes a score line, an indentation, or a crimp formed into the first sidewall. The top portions of the sidewalls include a cuff line about which the bag is capable of shifting. The bag shifts between (i) a flat configuration with the sidewalls positioned adjacent to each other, and (ii) a stand-up configuration with the sidewalls separated from each other. In the stand-up configuration, the bag has a substantially flat base. The bag also can be shifted to a cuffed position with the bag being folded over the cuff line of each of the sidewalls such that the cuff region forms an opening to the bag.