Invention Grant
- Patent Title: Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
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Application No.: US14775232Application Date: 2014-03-14
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Publication No.: US09776972B2Publication Date: 2017-10-03
- Inventor: Richard Chesworth , Lorna Helen Mitchell , Gideon Shapiro , Paula Ann Boriack-Sjodin , Oscar Miguel Moradei , Lei Jin , Kenneth W. Duncan
- Applicant: Epizyme, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Epizyme Inc.
- Current Assignee: Epizyme Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2014/029583 WO 20140314
- International Announcement: WO2014/178954 WO 20141106
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07D405/04 ; C07D405/06 ; C07D405/10 ; C07D405/12 ; C07D403/12 ; C07D413/04 ; C07D233/64 ; C07D401/06
Abstract:
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
Public/Granted literature
- US20160137609A1 PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Public/Granted day:2016-05-19
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