Invention Grant
- Patent Title: 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
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Application No.: US15296292Application Date: 2016-10-18
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Publication No.: US09776978B2Publication Date: 2017-10-03
- Inventor: Pottayil Govindan Nair Sasikumar , Muralidhara Ramachandra , Seetharamaiah Setty Sudarshan Naremaddepalli
- Applicant: Pottayil Govindan Nair Sasikumar , Muralidhara Ramachandra , Seetharamaiah Setty Sudarshan Naremaddepalli
- Applicant Address: IN Bangalore
- Assignee: Aurigene Discovery Technologies Limited
- Current Assignee: Aurigene Discovery Technologies Limited
- Current Assignee Address: IN Bangalore
- Agent Benjamin Aaron Adler
- Priority: IN4012/CHE/2013 20130906
- Main IPC: C07D285/12
- IPC: C07D285/12 ; C07D271/10 ; A61K31/433 ; A61K45/06 ; A61K31/4245
Abstract:
The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
Public/Granted literature
- US20170101387A1 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives as Immunomodulators Public/Granted day:2017-04-13
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