Invention Grant
- Patent Title: Pyrazolylbenzo[d]imidazole derivatives
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Application No.: US14775240Application Date: 2014-03-07
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Publication No.: US09776988B2Publication Date: 2017-10-03
- Inventor: Daria Zdzalik , Joanna Lipner , Maciej Wieczorek , Karolina Dzwonek , Abdellah Yamani , Krzysztof Dubiel , Monika Lamparska-Przybysz , Paulina Grygielewicz , Aleksandra Stanczak
- Applicant: CELON PHARMA S.A.
- Applicant Address: PL Kielpin/Lomianki
- Assignee: Celon Pharma S.A.
- Current Assignee: Celon Pharma S.A.
- Current Assignee Address: PL Kielpin/Lomianki
- Agency: Cooper & Dunham LLP
- Agent Gary J. Gershik
- Priority: PL403149 20130314
- International Application: PCT/IB2014/059515 WO 20140307
- International Announcement: WO2014/141015 WO 20140918
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D401/14 ; C07D409/14 ; C07D403/14
![Pyrazolylbenzo[d]imidazole derivatives](/abs-image/US/2017/10/03/US09776988B2/abs.jpg.150x150.jpg)
Abstract:
A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents —X-Q-P, wherein X is absent or represents —CH2—, —C(O)—, or —C(O)NH—(CH2)k—, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, —(CH2)l—NR2R3, or —(CH2)m—C(O)—NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, —NH— or —N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)
Public/Granted literature
- US20160039794A1 PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES Public/Granted day:2016-02-11
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