Invention Grant
- Patent Title: Macrocycles with aromatic P2′ groups as factor xia inhibitors
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Application No.: US15115314Application Date: 2015-01-30
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Publication No.: US09777001B2Publication Date: 2017-10-03
- Inventor: James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Andrew K. Dilger , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J. P. Pinto , Michael J. Orwat , Leon M. Smith, II
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2015/013652 WO 20150130
- International Announcement: WO2015/116885 WO 20150806
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D471/08 ; C07D487/08 ; C07D403/14 ; C07D471/18 ; C07D403/06

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20170096429A1 MACROCYCLES WITH AROMATIC P2' GROUPS AS FACTOR XIA INHIBITORS Public/Granted day:2017-04-06
Information query
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