Invention Grant
![Substituted furo[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents](/docs/US/2017-10-03/US09777012B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted furo[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
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Application No.: US14971121Application Date: 2015-12-16
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Publication No.: US09777012B2Publication Date: 2017-10-03
- Inventor: Aleem Gangjee
- Applicant: Duquesne University of the Holy Spirit
- Applicant Address: US PA Pittsburgh
- Assignee: Duquesne University of the Holy Spirit
- Current Assignee: Duquesne University of the Holy Spirit
- Current Assignee Address: US PA Pittsburgh
- Agency: Eckert Seamans Cherin & Mellott, LLC
- Agent Carol A. Marmo
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D491/048
![Substituted furo[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents](/abs-image/US/2017/10/03/US09777012B2/abs.jpg.150x150.jpg)
Abstract:
Compounds of Formula I: and compounds of Formula II: are provided. Pharmaceutical compositions comprising either the compound of Formula I or Formula II are disclosed. Methods of treating patients having cancer are provided by administering to the patient a therapeutically effective amount of one or more compounds having Formula I or Formula II to treat the patient. The compounds of Formula I or II are preferably conformationally restricted furo[2,3-d]pyrimidines having dual inhibition of microtubule assembly and receptor tyrosine kinases.
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