Invention Grant
- Patent Title: Methods and compositions for treating autoimmune disorders by targeting Kv1.3 ion channels with functionalized lipid-derived nanovesicles
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Application No.: US14863525Application Date: 2015-09-24
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Publication No.: US09777279B2Publication Date: 2017-10-03
- Inventor: Laura Conforti , Yeoheung Yun
- Applicant: University of Cincinnati , North Carolina Agricultural and Technical State University
- Applicant Address: US OH Cincinnati US NC Greensboro
- Assignee: University of Cincinnati,North Carolina Agricultural and Technical State University
- Current Assignee: University of Cincinnati,North Carolina Agricultural and Technical State University
- Current Assignee Address: US OH Cincinnati US NC Greensboro
- Agency: Dinsmore & Shohl LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/713 ; A61K9/00 ; A61K47/48 ; A61K9/127 ; C07K16/28
Abstract:
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.
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