A method and system for optimizing a human supervised cyber-physical system determines a state of the human operator based on data from multiple psycho physiological sensors, determines a state of each of multiple cyber-physical systems in the human supervised cyber-physical system based on data provided by the cyber-physical systems, and fuses the state of the human operator and the state of each of the plurality of cyber-physical systems into a single state of the human supervised cyber-physical system. The single state is then used to generate recommendations for optimizing a user interface and to generate high level control signals for the cyber-physical systems.