A method and system facilitate communication with a patient on an outpatient oral oncology regimen. The method and system facilitate creating an initial contact guide to direct a patient interaction occurring at the beginning of the outpatient oral oncology regimen and using the initial contact guide to conduct an initial contact with the patient using the branching logic of the initial contact guide to determine which initial contact guide questions and informational scripts to present based on information provided by the patient. The method and system further facilitate creating a secondary contact guide to conduct a secondary, follow-up contact with the patient using the branching logic of the secondary contact guide to determine which secondary contact guide questions and informational scripts to present based on information provided by the patient.