Systems and methods are provided that may be employed in a network environment to implement load balancing for multi-network interface controller (NIC) teaming applications using pause frame flow control communications received at an information handling system in situations where a given data path through a given NIC of the information handling system and a corresponding network switch is heavily loaded or otherwise congested relative to one or more other more lightly loaded data paths through other NICs of the information handling system and their corresponding network switches.