This invention generally relates to a shoe in which an orthopedic adjustment has been integrated into the construction of the shoe itself. The invention entails adjusting one or more of the soles or other construction features of the shoe itself in order to accommodate a medical condition or treatment regimen. In particular, in instances of abnormalities in the knee joint, there is a need to redistribute the weight of the body from an afflicted symptomatic medial compartment of the knee to an un-afflicted and asymptomatic, or lesser effected and less symptomatic compartment so as to relieve the pain and stress at the most afflicted and most symptomatic compartment. Benefits are also achieved by reducing a common ankle injury, and by improving lateral cutting, cornering, and push off maneuvers. The present invention achieves all this by laterally wedging the sole of a shoe, where the angle is chosen to counter and redistribute the weight of the body accordingly thereby changing the axial load on the knee and ankle joints.