Invention Grant
- Patent Title: Anti-virulance compositions and methods
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Application No.: US14435387Application Date: 2013-10-14
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Publication No.: US09782363B2Publication Date: 2017-10-10
- Inventor: Menachem Shoham , Rajesh Viswanathan , Guanping Yu
- Applicant: Case Western Reserve University
- Applicant Address: US OH Cleveland
- Assignee: Case Western Reserve University
- Current Assignee: Case Western Reserve University
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- International Application: PCT/US2013/064800 WO 20131014
- International Announcement: WO2014/059404 WO 20140417
- Main IPC: A61K31/12
- IPC: A61K31/12 ; A61K31/192 ; A61K31/235 ; C12N1/20 ; A61K45/06 ; A61K9/00 ; A61K31/122
Abstract:
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.
Public/Granted literature
- US20150265550A1 ANTI-VIRULANCE COMPOSITIONS AND METHODS Public/Granted day:2015-09-24
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