The present multi-seal dock seal has a pair of side seal assemblies that form both a compression seal and a wipe seal with a trailer. The side seal assembly secure to the building wall along the door opening. A wipe seal pad is positioned in front of a compression pad by an extension pad. The flexible pads are formed of polyurethane foam wrapped with a PVC vinyl coated polyester cover. The wipe and extension pads are more rigid than the compression pads, and the compression and extension pads are joined together to further support the extension pad. The side seal assemblies provide sealing zones to accommodate a wide range of truck and trailer types. The multiple seals formed by the multi-seal dock seal ensure a good seal with the trailer when the trailer fully backs into the bay, and when an obstruction prevents it from fully backing into the bay.