Invention Grant
- Patent Title: Water soluble 4-azapodophyllotoxin analogs
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Application No.: US15111711Application Date: 2015-01-15
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Publication No.: US09783547B2Publication Date: 2017-10-10
- Inventor: Guy Chabot , Sylviane Giorgi-Renault , Stéphanie Desbene-Finck , Philippe Helissey , Raphaël Labruere , Marlène Testud , Daniel Scherman
- Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE PARIS DESCARTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS
- Applicant Address: FR Paris FR Paris FR Paris FR Paris
- Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE PARIS DESCARTES,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS
- Current Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE PARIS DESCARTES,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS
- Current Assignee Address: FR Paris FR Paris FR Paris FR Paris
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: EP14305056 20140115
- International Application: PCT/EP2015/050702 WO 20150115
- International Announcement: WO2015/107119 WO 20150723
- Main IPC: C07D219/10
- IPC: C07D219/10 ; C07D491/056 ; A61K31/473 ; A61K31/4741 ; A61K31/513 ; A61K31/519 ; A61K31/675 ; A61K31/704 ; A61K33/24 ; A61K45/06
Abstract:
The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R1, R2, R3, R4 and Ar are as defined in claim 1, preferably a pharmaceutically acceptable salt thereof, optionally in the form of a solvate, a composition comprising said analogs, their use as medicament, in particular for the treatment of cancer, and a process for their preparation.
Public/Granted literature
- US20160333022A1 WATER SOLUBLE 4-AZAPODOPHYLLOTOXIN ANALOGS Public/Granted day:2016-11-17
Information query
