- Patent Title: Method for activating Oct4 for induction of pluripotent stem cells
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Application No.: US14411506Application Date: 2012-06-29
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Publication No.: US09783786B2Publication Date: 2017-10-10
- Inventor: Ralf Mrowka , Gunter Wolf , Stefan Wolfl , Xinlai Cheng
- Applicant: Ralf Mrowka , Gunter Wolf , Stefan Wolfl , Xinlai Cheng
- Applicant Address: DE Jena DE Dossenheim
- Assignee: UNIVERSITATSKLINIKUM JENA,Stefan Wolfl
- Current Assignee: UNIVERSITATSKLINIKUM JENA,Stefan Wolfl
- Current Assignee Address: DE Jena DE Dossenheim
- Agency: JMB Davis Ben-David
- International Application: PCT/EP2012/062725 WO 20120629
- International Announcement: WO2014/000814 WO 20140103
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N5/074
Abstract:
The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.
Public/Granted literature
- US20150267173A1 METHOD FOR ACTIVATING OCT4 FOR INDUCTION OF PLURIPOTENT STEM CELLS Public/Granted day:2015-09-24
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