- Patent Title: Cell for use in immunotherapy which contains modified nucleic acid construct encoding wilms tumor gene product or fragment thereof, method for producing said cell, and said nucleic acid construct
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Application No.: US14235333Application Date: 2012-07-30
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Publication No.: US09783821B2Publication Date: 2017-10-10
- Inventor: Shin-ichiro Fujii , Kanako Shimizu , Jun Shinga
- Applicant: Shin-ichiro Fujii , Kanako Shimizu , Jun Shinga
- Applicant Address: JP Saitama
- Assignee: RIKEN
- Current Assignee: RIKEN
- Current Assignee Address: JP Saitama
- Agency: Casimir Jones, SC
- Priority: JP2011-167796 20110729
- International Application: PCT/JP2012/069377 WO 20120730
- International Announcement: WO2013/018778 WO 20130207
- Main IPC: C12N15/85
- IPC: C12N15/85 ; A61K39/00 ; C07K14/47 ; C07K14/82
Abstract:
A cell of the present invention contains a nucleic acid construct encoding a WT1 gene product or a fragment of the WT1 gene product. The nucleic acid construct contains (i) a region encoding a desired fragment of the WT1 gene product and (ii) only AUG as a functional start codon. The present invention can provide a cell into which the nucleic acid construct is introduced so that an expression level of a WT1 gene product or a fragment of the WT1 gene product is remarkably enhanced.
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