• Patent Title: Detection of immune cells, in particular T cells through DNA-methylation analysis of the genes CCR6 and BLR1
  • Application No.: US13636556
    Application Date: 2011-04-29
  • Publication No.: US09783846B2
    Publication Date: 2017-10-10
  • Inventor: Sven Olek
  • Applicant: Sven Olek
  • Applicant Address: DE Berlin
  • Assignee: EPIONTIS GMBH
  • Current Assignee: EPIONTIS GMBH
  • Current Assignee Address: DE Berlin
  • Agency: Saliwanchik, Lloyd & Eisenschenk
  • International Application: PCT/EP2011/056871 WO 20110429
  • International Announcement: WO2011/135088 WO 20111103
  • Main IPC: C12Q1/68
  • IPC: C12Q1/68
Detection of immune cells, in particular T cells through DNA-methylation analysis of the genes CCR6 and BLR1
Abstract:
The present invention relates to a method, in particular an in vitro method, for identifying certain immune cells of a mammal, comprising analyzing the methylation status of at least one CpG position in the gene CCR6 and/or BLR1 or an orthologous or paralogous gene thereof, and the use of DNA-methylation analysis of the genes of the proteins CCR6 and/or BLR1 for a detection and quality assurance and control of certain immune cells. In particular, the present invention relates to analyzing the methylation status of at least one CpG position in the gene CCR6 in T cells. Furthermore, the present invention relates to a kit for performing the above methods, as well as to respective uses.
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