A tilt-type anti-shake compensation structure for auto-focus module includes an auto-focus module having a lens assembly held thereto and driving the latter to move forward and rearward in a light entering path, i.e. in z-axis direction, so as to focus a captured image; an outer frame enclosing the auto-focus module therein, and having an elastic supporting member provided therein to connect to and between upper ends of the outer frame and the auto-focus module; and a compensation driving unit arranged behind the auto-focus module for driving the auto-focus module to tilt leftward and rightward on x-axis, or forward and rearward on y-axis, within the outer frame, so as to compensate any image deviation due to shake caused by hands. The anti-shake structure is simple and can quickly compensate shake caused by hands.