Example systems, methods, and devices are disclosed for scheduling traffic by a media agnostic universal serial bus protocol adaptive layer. In one embodiment, a method can include determining, by a processor, a first bitmask including first binary information about a state of a plurality of universal serial bus traffic classes, selecting, by the processor, one or more universal serial bus traffic classes to service based at least in part on the first binary information, determining, by the processor, a second bitmask including second binary information about a state of a plurality of universal serial bus endpoint queues, each universal serial bus endpoint queue including a plurality of universal serial bus endpoints, and selecting, by the processor, one or more universal serial bus endpoint queues to service based at least in part on the second binary information.