Systems and methods are provided for refined data reconstruction. In accordance with one aspect, the framework performs a first four-dimensional reconstruction of time-varying data to generate a four-dimensional Digital Subtraction Angiography (DSA) dataset of an object of interest. The framework extracts a volume of interest from the four-dimensional DSA dataset to generate a volume array. The volume of interest may be refined based on the volume array to generate a refined dataset. A second four-dimensional reconstruction may then be performed based on the refined dataset to generate a zoomed-in four-dimensional representation of the volume of interest.