A system for removing thermal energy generated by radioactive materials is provided. The system comprises an air-cooled shell-and-tube heat exchanger, comprising a shell and plurality of heat exchange tubes arranged in a substantially vertical orientation within the shell, the heat exchange tubes comprising interior cavities that collectively form a tube-side fluid path, the shell forming a shell-side fluid path that extends from an air inlet of the shell to an air outlet of the shell, the air inlet at a lower elevation than the air outlet; a heat rejection closed-loop fluid circuit comprising the tube-side fluid path, a coolant fluid flowing through the heat rejection closed-loop fluid circuit, the heat rejection closed-loop fluid circuit thermally coupled to the radioactive materials; and the air-cooled shell-and-tube heat exchanger transferring thermal energy from the coolant fluid flowing through the tube-side fluid path to air flowing through the shell-side fluid path.