Presently disclosed are methods and systems to dynamically adjust base station configurations based on the altitude of the base station. One embodiment takes the form of a method carried out by a cellular base station system. The method includes determining that an altitude of a cellular base station exceeds a threshold. The method also includes configuring the cellular base station with one or more operational parameters based on the determined altitude. The one or more operational parameters includes at least one parameter selected from the group consisting of a transmit power, a carrier frequency, a handoff parameter, and a whitelist.