Systems and associated methods for reciprocity calibration of MIMO wireless communication are disclosed. In one embodiment, a method includes receiving, by a base station, a first set of pilot symbols by receivers (RXes) of the base station based on a first pilot symbol transmitted from a transmitter (TX) of at least one reference antenna, transmitting, by the base station, a second pilot symbol by TXes of the base station, wherein the transmitted second pilot symbol is received by an RX of the at least one reference antenna as a second set of r0,i pilot symbols calculating non-reciprocity compensation factors based on the first set of pilot symbols and the second set of pilot symbols.