Disclosed are a method and device for processing and indicating downlink data. The method for processing the downlink data includes: a user equipment (UE) receiving multiple sets of resource indication information configured for the UE by a base station and transmitted by the base station via a high-layer signaling; the UE receiving a subframe transmitted by the base station, acquiring downlink grant indication information in the subframe; the UE selecting from the multiple sets of resource indication information the resource indication information matching the downlink grant indication information, wherein the resource indication information is used for indicating a resource location having interference present, or, the resource location having interference present and interference information corresponding to the resource location; and the UE processing on the resource location the interference of the downlink data transmitted to the UE. The disclosure allows the implementation of coordinated transmission among different nodes to one UE.