Signal interference associated with multi-user multiple-input multiple-output (MIMO) full-duplex wireless communication systems is reduced. In an example, first streams are received by a MIMO base station from uplink user devices based on a first availability of channel matrices and second streams are transmitted to downlink user devices based on a second availability of the channel matrices. A weighted sum of a first data rate for a first linear transceiver matrix and a second data rate of a second linear transceiver matrix is maximized based on the channel matrices, the first streams, and the second streams. The base station generates a first linear transceiver vector used in transmission of the first streams to the base station from the uplink user devices and a second linear transceiver vector used in transmission of the second streams from the base station to the downlink user devices.