An optical fiber having both low macrobend loss and low microbend loss. The fiber has a central core region, a first (inner) cladding region surrounding the central core region and having an outer radius r2>16 microns and relative refractive index Δ2, and a second (outer) cladding region surrounding the first cladding region having relative refractive index, Δ3, wherein Δ1>Δ3>Δ2. The difference between Δ3 and Δ2 is greater than 0.12 percent. The fiber exhibits a 22 m cable cutoff less than or equal to 1260 nm, and r1/r2 is greater or equal to 0.24 and bend loss at 1550 nm for a 15 mm diameter mandrel of less than 0.5 dB/turn.