A charge rebalancing integration circuit can help keep an output node of a front-end integration circuit within a specified range, e.g., without requiring resetting of the integration capacitor. The process of monitoring and rebalancing the integration circuit can operate on a much shorter time base than the integration time period, which can allow for multiple charge balancing charge transfer events during the integration time period, and sampling of the integration capacitor once per integration time period, such as at the end of that integration time period. Information about the charge rebalancing can be used to adjust subsequent discrete-time signal processing, such as digitized values of the samples. Improved dynamic range and noise performance is possible. Computed tomography (CT) imaging and other use cases are described, including those with variable integration periods.